The NOL8 Polyclonal Antibody (PACO06971) is a valuable tool for researchers studying NOL8, a protein involved in RNA processing and ribosome biogenesis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the NOL8 protein, this antibody enables the detection and analysis of NOL8 in a variety of cell types, making it an essential component for studies in molecular biology and cancer research.NOL8 is known for its role in RNA metabolism, specifically in the maturation of ribosomal RNA and the assembly of ribosomes.
Dysregulation of NOL8 has been implicated in various diseases, including cancer and developmental disorders. Research into the function of NOL8 is crucial for understanding its impact on cellular processes and its potential as a therapeutic target in disease treatment.Overall, the NOL8 Polyclonal Antibody (PACO06971) provides researchers with a reliable tool for investigating the role of NOL8 in cellular function and disease pathogenesis. Its specificity and sensitivity make it an indispensable resource for advancing our knowledge of RNA biology and its implications for human health.
Antibody Name:
NOL8 Antibody (PACO06971)
Antibody SKU:
PACO06971
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from the C-terminal region of human Nop132.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of NIH-3T3 cells using Nop132 Polyclonal Antibody.
Western Blot analysis of 3T3 cells using Nop132 Polyclonal Antibody.
Synonyms:
NOL8; C9orf34; NOP132; Nucleolar protein 8; Nucleolar protein Nop132
UniProt Protein Function:
NOL8: Plays an essential role in the survival of diffuse-type gastric cancer cells. Acts as a nucleolar anchoring protein for DDX47. May be involved in regulation of gene expression at the post-transcriptional level or in ribosome biogenesis in cancer cells. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Nucleolus; RNA-bindingChromosomal Location of Human Ortholog: 9q22.31Cellular Component: cytoplasm; nucleolus; nucleusMolecular Function: nucleotide binding; protein bindingBiological Process: DNA replication; positive regulation of cell growth; rRNA processing
UniProt Protein Details:
NCBI Summary:
NOL8 binds Ras-related GTP-binding proteins (see MIM 608267) and plays a role in cell growth (Sekiguchi et al., 2004 [PubMed 14660641]).[supplied by OMIM, Mar 2008]
