The NPAS4 Polyclonal Antibody (PAC022467) is an essential tool for researchers studying the NPAS4 protein, a transcription factor involved in neuronal activity and brain development. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot assays. By specifically binding to NPAS4, this antibody enables precise detection and analysis of the protein in various cell types, making it an ideal choice for neuroscience and neurodevelopment research.NPAS4, also known as neuronal PAS domain protein 4, plays a crucial role in regulating gene expression in response to neuronal activity, impacting synaptic plasticity and neuronal survival.
Its involvement in neuronal function and development makes it a key target for investigating neurological disorders, brain injuries, and cognitive function. Understanding the functions of NPAS4 is vital for developing therapeutic strategies to manipulate neuronal activity and promote brain health in various neurological conditions.
Antibody Name:
NPAS4 Antibody (PACO22467)
Antibody SKU:
PACO22467
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:50-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthesized peptide derived from internal of human NPAS4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry analysis of paraffin-embedded human brain tissue using NPAS4 antibody.
Background:
Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene.
Synonyms:
Neuronal PAS domain-containing protein 4; Neuronal PAS4; HLH-PAS transcription factor NXF;
UniProt Protein Function:
NPAS4: Acts as a transcriptional activator in the presence of ARNT. Can activate the CME (CNS midline enhancer) element and the expression of the drebrin gene.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 11q13Cellular Component: transcription factor complex; nucleusMolecular Function: signal transducer activity; protein heterodimerization activityBiological Process: transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; signal transduction
UniProt Protein Details:
NCBI Summary:
NXF is a member of the basic helix-loop-helix-PER (MIM 602260)-ARNT (MIM 126110)-SIM (see SIM2; MIM 600892) (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008]
