The NPR3 Polyclonal Antibody (CAB8138) is a valuable tool for researchers studying NPR3, a cell surface receptor involved in the regulation of natriuretic peptide signaling. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the NPR3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an excellent choice for studies in cardiovascular biology, renal physiology, and endocrinology.
NPR3, also known as the clearance receptor for natriuretic peptides, plays a crucial role in the control of blood pressure, fluid balance, and cardiac function. Dysregulation of NPR3 signaling has been implicated in various cardiovascular disorders, making it a promising target for therapeutic interventions. Investigating the function and expression of NPR3 using this polyclonal antibody is essential for understanding its role in health and disease, and for developing novel strategies for treating cardiovascular conditions.
Product Name:
NPR3 Rabbit Polyclonal Antibody
SKU:
CAB8138
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 272-541 of human NPR3 (NP_001191304.1).
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
4883
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using NPR3 Rabbit pAb (CAB8138) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
