The NR1I3 Polyclonal Antibody is a valuable tool for researchers studying NR1I3, a nuclear receptor involved in the regulation of drug metabolism and xenobiotic responses. This antibody is produced in rabbits and has been validated for Western blot applications, ensuring accurate and reliable results.NR1I3, also known as the pregnane X receptor (PXR), plays a crucial role in the body's defense against harmful substances by regulating the expression of drug-metabolizing enzymes and transporters.
Understanding the function of NR1I3 is essential for developing personalized medicine and optimizing drug therapies for patients.With its high reactivity with human samples, the NR1I3 Polyclonal Antibody is suitable for a range of research applications, including studies on drug metabolism, pharmacogenomics, and toxicology. Its specificity for NR1I3 protein makes it an invaluable tool for scientists investigating the role of nuclear receptors in health and disease.
Product Name:
NR1I3 Polyclonal Antibody
SKU:
CAB21765
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 99-352 of human NR1I3 (NP_001070948.1).
This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. In addition to drug metabolism, the CAR protein is also reported to regulate genes involved in glucose metabolism, lipid metabolism, cell proliferation, and circadian clock regulation. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9970
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse ovary, using NR1I3 Rabbit pAb (CAB21765) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
