The Neuregulin-3 (NRG3) Monoclonal Antibody (CAB19763) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced through a hybridoma fusion of mouse myeloma cells with spleen cells from immunized mice, offers high specificity and sensitivity for detecting NRG3 in various experimental settings.NRG3 is a crucial signaling molecule that plays a key role in various biological processes, including neuronal migration, synapse formation, and neurotransmission. Dysregulation of NRG3 has been implicated in neurodevelopmental disorders, schizophrenia, and other neurological conditions.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Neuregulin-3 (NRG3) Monoclonal Antibody
SKU:
CAB19763
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC2289
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.
Purification Method
Affinity purification
Gene ID
10718
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Neuregulin-3 (NRG3) Rabbit mAb (CAB19763) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 60s.
Western blot analysis of various lysates using Neuregulin-3 (NRG3) Rabbit mAb (CAB19763) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 180s.
