The OLFML3 Polyclonal Antibody (PAC052850) is specifically designed for researchers studying OLFML3, a secreted glycoprotein implicated in various biological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the OLFML3 protein, this antibody allows for the detection and analysis of OLFML3 in a wide range of cell types, making it an excellent tool for research in areas such as immunology and cancer biology.OLFML3, also known as Olfactomedin-like protein 3, has been linked to functions such as cell adhesion, angiogenesis, and inflammation.
Its potential involvement in these processes highlights its importance as a target for investigation in diseases such as cancer, cardiovascular disorders, and neurodegenerative conditions. Further exploration of OLFML3 activity could provide valuable insights into disease mechanisms and potentially lead to the development of novel therapeutic strategies aimed at targeting this protein.
Western Blot. Positive WB detected in: Rat skeletal muscle tissue. All lanes: OLFML3 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47, 44, 33 kDa. Observed band size: 47 kDa.
Immunohistochemistry of paraffin-embedded human liver tissue using PACO52850 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO52850 at dilution of 1:100.
Background:
Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation (By similarity). May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes.
Synonyms:
Olfactomedin-like protein 3 (HNOEL-iso) (hOLF44), OLFML3
UniProt Protein Function:
OLFML3: Secreted scaffold protein that plays an essential role in dorsoventral patterning during early development. Stabilizes axial formation by restricting chordin (CHRD) activity on the dorsal side. Acts by facilitating the association between the tolloid proteases and their substrate chordin (CHRD), leading to enhance chordin (CHRD) degradation. May have matrix-related function involved in placental and embryonic development, or play a similar role in other physiological processes. Belongs to the OLFML3 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 1p13.2
