The PACS2 polyclonal antibody (PAC057908) is a high-quality research tool designed for studying the protein PACS2, which is involved in various cellular processes including protein trafficking and autophagy. This antibody, generated in rabbits, exhibits strong reactivity specifically with human samples and has been validated for use in Western blot applications. By binding to the PACS2 protein, researchers can easily detect and analyze its expression in different cell types, making it a valuable tool for studies in cell biology and neurodegenerative diseases.PACS2, also known as phosphofurin acidic cluster sorting protein 2, plays a crucial role in the regulation of intracellular trafficking and organelle function.
Dysregulation of PACS2 has been implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, highlighting its importance in cellular homeostasis. By studying the function of PACS2, researchers can gain insights into the mechanisms underlying these diseases and potentially identify novel therapeutic targets for intervention.Overall, the PACS2 polyclonal antibody is a reliable tool for investigating the function and role of PACS2 in various cellular processes and disease states. Its specificity, sensitivity, and versatility make it an essential component for researchers interested in unraveling the complexities of cellular biology and neurodegenerative disorders.
Antibody Name:
PACS2 Antibody (PACO57908)
Antibody SKU:
PACO57908
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Phosphofurin acid, c cluster sorting protein 2 protein (268-465AA)
IHC image of PACO57908 diluted at 1:400 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO57908 diluted at 1:400 and staining in paraffin-embedded human melanoma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acid, c cluster-containing ion channels to distinct subcellular compartments.
Synonyms:
Phosphofurin acid, c cluster sorting protein 2 (PACS-2) (PACS1-like protein), PACS2, KIAA0602 PACS1L
UniProt Protein Function:
PACS2: Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments. Belongs to the PACS family. 3 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 14q32.33Cellular Component: endoplasmic reticulumBiological Process: autophagic vacuole formation
