The pan-Trk Monoclonal Antibody (CAB23241) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced through monoclonal antibody technology, exhibits high specificity and sensitivity for detecting TRK proteins in a variety of biological samples.TRK proteins, including TRKA, TRKB, and TRKC, play crucial roles in neuronal development and function, as well as in various cancers where they can be overexpressed or mutated. The Pan-TRK Monoclonal Antibody allows for precise detection and analysis of these proteins in Western blot applications, making it an essential tool for researchers investigating the role of TRK proteins in cancer biology and neurobiology.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
pan-Trk Monoclonal Antibody
SKU:
CAB23241
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC59539
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:
Email for sequence
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:500 - 1:1000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Positive Sample:
SH-SY5Y, Mouse brain, Rat brain
Cellular Localization:
Axon, Dendrite, Early Endosome, Late Endosome, Plasma Membrane.
Observed MW:
120-140kDa
Neurotrophic tyrosine kinase (NTRK) is a family of receptor tyrosine kinase.The NTRK gene family contains three members, NTRK1, NTRK2 and NTRK3, which produce TRKA, TRKB and TRKC proteins, respectively.TRK kinases leads to cell differentiation and may play important roles in normal neural functions.Rearrangements in the NTRK genes can result in two genes fusing together and producing altered TRK proteins, which can lead to uncontrolled growth of cancer cells. Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are an actionable biomarker for cancer therapy and can be found in over 25 different types of cancer.
Purification Method
Affinity purification
Gene ID
4914 4915 4916
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using pan-Trk Rabbit mAb (CAB23241) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC): Mouse spleen. Exposure time: 30s.
Western blot analysis of various lysates, using pan-Trk Rabbit mAb (CAB23241) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC): U-937. Exposure time: 30s.
