The PARP11 Polyclonal Antibody (PAC016843) is a valuable tool for researchers studying PARP11, a member of the poly(ADP-ribose) polymerase (PARP) family of enzymes involved in DNA damage repair and genomic stability. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it suitable for Western blot applications.PARP11 is known to play a role in various cellular processes, including DNA repair, transcriptional regulation, and cell cycle control. Dysregulation of PARP11 activity has been associated with diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases.
By targeting PARP11, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify novel therapeutic strategies.The PARP11 Polyclonal Antibody enables the detection and analysis of PARP11 protein levels in different cell types, offering a versatile tool for investigating its functions in normal physiology and disease states. Its applications in immunology, oncology, and molecular biology make it a valuable asset for research laboratories seeking to advance our understanding of PARP11 biology.
Antibody Name:
PARP11 Antibody (PACO16843)
Antibody SKU:
PACO16843
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human PARP11
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO16843(PARP11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using PACO16843(PARP11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
Poly(ADP-ribosylation) is a method of DNA damage-dependent posttranslational modification that helps to rescue injured proliferating cells from cell death. The PARP (poly(ADP-ribose) polymerase) proteins comprise a superfamily of enzymes that functionally modify histones and other nuclear proteins, thereby preventing cell death. PARPs use NAD+ as a substrate to catalytically transfer ADP-ribose residues onto protein acceptors; a process that, when repeated multiple times, leads to the formation of poly(ADPribose) chains on the protein.
