The PCDHA2 Polyclonal Antibody (PACO11095) is a valuable tool for researchers studying the PCDHA2 protein, a member of the protocadherin alpha gene cluster. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the PCDHA2 protein, this antibody enables the detection and analysis of PCDHA2 in various cell types, making it ideal for investigations in the fields of neuroscience and developmental biology.
PCDHA2 is a cell adhesion molecule that plays a crucial role in neuronal development and synaptic connectivity. Its involvement in neuronal wiring and synapse formation makes it a key target for studies on neurodevelopmental disorders, such as autism and schizophrenia. Understanding the functions of PCDHA2 is essential for unraveling the mechanisms underlying brain development and function, potentially leading to the discovery of novel therapeutic strategies for neurological conditions.
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
