The PCDHGB7 Polyclonal Antibody (PAC064451) is a powerful tool for researchers investigating the PCDHGB7 protein, which plays a crucial role in cell adhesion and communication. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the PCDHGB7 protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in cell biology, developmental biology, and cancer research.PCDHGB7, a member of the protocadherin gamma subfamily, is essential for maintaining tissue integrity and proper cell signaling.
Its role in cell-cell adhesion and communication makes it a key player in various physiological processes, including neuronal development, immune cell interactions, and tumorigenesis. Researchers studying cell adhesion, signal transduction, or cancer biology will benefit greatly from the use of this antibody to uncover the mechanisms underlying PCDHGB7-mediated functions. Unlocking the mysteries of PCDHGB7's function can lead to advancements in understanding cell behavior and developing targeted therapies for diseases related to cell adhesion dysregulation.
Antibody Name:
PCDHGB7 Antibody (PACO64451)
Antibody SKU:
PACO64451
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
IF:1:100-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Protocadherin gamma-B7 protein (719-929AA)
Immunofluorescence staining of SH-SY5Y cells with PACO64451 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Synonyms:
Protocadherin gamma-B7 (PCDH-gamma-B7), PCDHGB7
UniProt Protein Function:
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
UniProt Protein Details:
NCBI Summary:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
