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Key Features

PE Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3108)

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SKU AGEL3108
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Reactivity Mouse
Host Species Syrian Hamster
Isotype Syrian Hamster IgG
Clone 2F1
Conjugation PE
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Description

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PE Anti-Human/Mouse KLRG-1 Antibody [2F1]

The PE Anti-Human/Mouse KLRG-1 Antibody (2F1) offered by AssayGenie (AGEL3108) is a specialized tool for researchers investigating the immune system and immunology. This antibody is targeted towards the KLRG-1 protein, a cell surface receptor involved in immune responses and the regulation of immune cell function.KLRG-1, also known as killer cell lectin-like receptor subfamily G member 1, is a marker of T cell differentiation and senescence. By binding specifically to KLRG-1, this antibody enables the detection and analysis of KLRG-1 expressing cells in both human and mouse samples. This feature makes it a valuable asset in studies focused on understanding T cell function, differentiation, and exhaustion.

The PE Anti-Human/Mouse KLRG-1 Antibody (2F1) is validated for use in flow cytometry applications, allowing for precise quantification and characterization of KLRG-1 expressing cells within a sample. This antibody's high specificity and reactivity make it a reliable tool for researchers exploring immune responses, immunotherapy, and immune cell modulation in various disease contexts.Overall, the PE Anti-Human/Mouse KLRG-1 Antibody (2F1) provides researchers with a powerful instrument to dissect the role of KLRG-1 in immune regulation, making it an essential reagent for studies in immunology, cancer research, and autoimmune disorders.

Product Title:PE Anti-Human/Mouse KLRG-1 Antibody [2F1]
SKU:AGEL3108
Size:20 Tests, 100 Tests, 200 Tests
Clone No:2F1
Synonyms:MAFA; 2F1-Ag;
Host Species:Syrian Hamster
Reactivity:Human;Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Isotype Control:PE Syrian Hamster IgG Isotype Control[SHG-1]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q96E93 O88713
Gene ID:10219,50928
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG5 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.

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