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PE Anti-Mouse CD105 Antibody [MJ7/18] (AGEL2473)

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SKU AGEL2473
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, κ
Clone MJ7/18
Conjugation PE
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Description

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PE Anti-Mouse CD105 Antibody [MJ7/18]

The PE Anti-Mouse CD105 Antibody (MJ7/18) from Assay Genie (AG-EL2473) is a highly specific and reliable tool for studying CD105, a cell surface marker involved in angiogenesis and endothelial cell function. This antibody, developed for use in flow cytometry applications, is suitable for detecting and quantifying CD105 expression in mouse samples. By binding specifically to CD105, this antibody allows for precise analysis of endothelial cells and vascular development in various experimental settings.CD105, also known as endoglin, is a key regulator of angiogenesis and vascular remodeling, playing crucial roles in both physiological and pathological processes such as tumor growth and wound healing.

Understanding the expression and function of CD105 is essential for unraveling its involvement in various diseases and conditions related to vascular biology. The PE Anti-Mouse CD105 Antibody (MJ7/18) provides researchers with a valuable tool for investigating the role of CD105 in angiogenesis and vascular biology, thereby contributing to the advancement of research in fields such as cancer biology, cardiovascular diseases, and regenerative medicine.

Product Title:PE Anti-Mouse CD105 Antibody [MJ7/18]
SKU:AGEL2473
Size:25µg, 100µg
Clone No:MJ7/18
Synonyms:Endoglin;END;Eng;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q63961
Gene ID:13805
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD105 is a 90 kD homodimeric type I integral membrane glycoprotein, also known as endoglin. It is expressed on endothelial cells (especially on angiogenic endothelial cells) and upregulated by hypoxia, activated monocytes, macrophages, bone marrow stromal cells, and some cytotrophoblasts. CD105 is a receptor for TGF-β1, TGF-β3 and modulates TGF-β signaling by interacting with TGF-β receptors I and/or II. CD105 also binds other growth factors such as actvin A, BMP-2, and BMP-7. CD105 has been show to be a useful marker for identifying proliferating endothelium involved in tumor angiogenesis and can be used for tumor imaging and prognosis, and has therapeutic potential for some solid tumors and other angiogenic diseases.

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