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PE/Cyanine7 Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3110)

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SKU AGEL3110
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Reactivity Mouse
Host Species Syrian Hamster
Isotype Syrian Hamster IgG
Clone 2F1
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Human/Mouse KLRG-1 Antibody [2F1]

The PE-Cyanine7 Anti-Human/Mouse KLRG-1 Antibody (2F1) from AssayGenie (AGEL3110) is a high-quality monoclonal antibody designed for research purposes. This antibody is specific for KLRG-1, a cell surface marker associated with immune cell activation and exhaustion. This antibody is suitable for flow cytometry applications and is optimized for detecting KLRG-1 expression in both human and mouse samples. With its PE-Cyanine7 conjugation, it provides bright and stable fluorescence signal, allowing for accurate and reliable quantification of KLRG-1 expression levels in various cell populations.

KLRG-1 is known to play a role in regulating immune responses, particularly in the context of T cell differentiation and exhaustion. Its expression pattern and functional relevance make it a valuable target for studies in immunology, cancer research, and infectious diseases. By using the PE-Cyanine7 Anti-Human/Mouse KLRG-1 Antibody (2F1), researchers can gain insights into the dynamics of immune cell populations and their roles in disease progression, leading to potential therapeutic applications in the future.

Product Title:PE/Cyanine7 Anti-Human/Mouse KLRG-1 Antibody [2F1]
SKU:AGEL3110
Size:20 Tests, 100 Tests, 200 Tests
Clone No:2F1
Synonyms:MAFA; 2F1-Ag;
Host Species:Syrian Hamster
Reactivity:Human;Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q96E93 O88713
Gene ID:10219,50928
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG9 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.

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