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PE/Cyanine7 Anti-Mouse CD335 Antibody [29A1.4] (AGEL3274)

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SKU AGEL3274
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, k
Clone 29A1.4
Conjugation PE/Cyanine7
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Description

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PE/Cyanine7 Anti-Mouse CD335 Antibody [29A1.4]

The PE-Cyanine7 Anti-Mouse CD335 Antibody (29A1.4) (AGEL3274) is a valuable tool for researchers studying natural killer cells in immune regulation and anti-tumor responses. This antibody, specifically designed for use in flow cytometry applications, targets the CD335 protein, also known as NKp46, which is a marker of natural killer cells. By binding to CD335, this antibody allows for the precise detection and analysis of NK cells in various samples, making it essential for studies in immunology and cancer research.NK cells are a crucial component of the immune system, playing a pivotal role in the surveillance and elimination of infected and tumor cells.

Understanding the function and regulation of NK cells, particularly through the CD335 marker, is essential for developing immunotherapies and strategies to enhance anti-tumor immune responses. This antibody, validated for use in mouse samples, provides researchers with a reliable tool to investigate the role of NK cells in cancer immunity and immune surveillance, paving the way for new insights and potential therapeutic interventions.

Product Title:PE/Cyanine7 Anti-Mouse CD335 Antibody [29A1.4]
SKU:AGEL3274
Size:25µg, 100µg
Clone No:29A1.4
Synonyms:Ly94;mAR-1;NK-p46;mNKp46;Lymphocyte antigen 94;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q8C567
Gene ID:17086
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD335, also known as NKp46, is a single-pass type I membrane protein of 46 kD. It belongs to the natural cytotoxicity receptor (NCR) family and contains two Ig-like (immunoglobulin-like) domains. It's expression is restricted to NK cells and a subset of NKT cells; it's not expressed in CD1d-restricted NKT cells. CD335 is a receptor for viral hemagglutinins and heparan sulfate proteoglycans and is involved in NK cell activation.

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