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PerCP/Cyanine5.5 Anti-Mouse CD8a Antibody [53-6.7] (AGEL2205)

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SKU AGEL2205
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Mouse
Host Species Rat
Isotype Rat IgG2a, κ
Clone 53-6.7
Conjugation PerCP/Cyanine5.5
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Description

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PerCP/Cyanine5.5 Anti-Mouse CD8a Antibody [53-6.7]

The PerCP-Cyanine5.5 Anti-Mouse CD8a Antibody (Clone: 53-6.7) available at www.assaygenie.com provides a reliable tool for the detection and analysis of CD8a, a key cell surface marker involved in immune response modulation. This antibody, produced using advanced technology, offers high reactivity with mouse samples and is optimized for flow cytometry applications. It specifically binds to CD8a, enabling precise identification and characterization of CD8a-positive cells in various experimental settings, making it an essential reagent for immunology and cancer research studies.CD8a, a crucial component of the immune system, plays a pivotal role in cytotoxic T cell function and immune surveillance.

It is integral in recognizing and eliminating infected or abnormal cells, making it an important target for investigating immune responses in health and disease. By exploring the expression and behavior of CD8a-positive cells, researchers can gain insights into the mechanisms underlying immune activation, tolerance, and dysfunction, offering valuable information for the development of novel therapeutic strategies in the fields of immunotherapy and infectious diseases.

Product Title:PerCP/Cyanine5.5 Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL2205
Size:50 Tests, 100 Tests, 200 Tests
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

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