The Phospho-DNMT1 (pS714) Polyclonal Antibody (CABP0021) is a valuable tool for researchers studying DNA methyltransferase 1 (DNMT1) and its phosphorylation at serine 714. DNMT1 is a crucial enzyme involved in the maintenance of DNA methylation patterns, with phosphorylation playing a role in its regulation and function.This antibody, produced in rabbits, is highly specific for detecting phospho-DNMT1 (pS714) in human samples and has been validated for use in Western blot applications. By targeting this specific phosphorylation site on DNMT1, researchers can gain insights into the regulatory mechanisms governing DNA methylation and gene expression.
The Phospho-DNMT1 (pS714) Polyclonal Antibody is particularly useful for investigations in epigenetics, cancer research, and developmental biology. Understanding the role of DNMT1 phosphorylation in these contexts can provide valuable information for developing targeted therapies and interventions that capitalize on epigenetic modifications in disease states.
Product Name:
Phospho-DNMT1-pS714 Rabbit Polyclonal Antibody
SKU:
CABP0021
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S714 of human DNMT1 (NP_001370.1).
This gene encodes an enzyme that transfers methyl groups to cytosine nucleotides of genomic DNA. This protein is the major enzyme responsible for maintaining methylation patterns following DNA replication and shows a preference for hemi-methylated DNA. Methylation of DNA is an important component of mammalian epigenetic gene regulation. Aberrant methylation patterns are found in human tumors and associated with developmental abnormalities. Variation in this gene has been associated with cerebellar ataxia, deafness, and narcolepsy, and neuropathy, hereditary sensory, type IE. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
1786
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of MCF-7 cells using Phospho-DNMT1-S714 antibody (CABP0021). Blue: DAPI for nuclear staining.
