The Phospho-PERK (T982) Monoclonal Antibody (CABP1420) is a powerful tool for researchers studying the PERK protein, a key regulator of the unfolded protein response (UPR) pathway. This antibody, produced using innovative monoclonal technology, specifically binds to the phosphorylated form of PERK at threonine 982, allowing for precise detection and analysis of this important signaling molecule.PERK, or protein kinase RNA-like endoplasmic reticulum kinase, is essential for the cellular response to ER stress, playing a crucial role in maintaining cellular homeostasis and promoting cell survival under stressful conditions. Phosphorylation at threonine 982 is a key regulatory event in PERK activation, making this antibody an invaluable tool for studying the UPR pathway and its implications in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes.
By enabling researchers to specifically target and study the phosphorylated form of PERK, the CABP1420 antibody facilitates a deeper understanding of UPR signaling and its implications in disease pathology. Its high specificity and sensitivity make it ideal for use in applications such as Western blotting and immunofluorescence, providing researchers with valuable insights into the complex mechanisms of cellular stress response.
Product Name:
Phospho-PERK-T982 Monoclonal Antibody
SKU:
CABP1420
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T982 of human PERK.
Tested Applications:
IHC-PELISA
Recommended Dilution:
IHC-P,1:50 - 1:200
Synonyms:
PEK; WRS; PERK; Phospho-PERK-T982
Conjugate:
Unconjugated
Cellular Localization:
Endoplasmic reticulum membrane.
Calculated MW:
125kDa
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
Purification Method:
Affinity purification
Gene ID:
9451
Clone Number:
ARC58933
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human tonsil using Phospho-PERK-T982 Rabbit mAb (CABP1420) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
