The PTPN6 (Y536) Polyclonal Antibody (CABP0440) is a highly specific antibody designed for research involving phosphorylated PTPN6, a critical regulator of immune signaling pathways. PTPN6, also known as SHP-1, is a non-receptor protein tyrosine phosphatase that plays a key role in the negative regulation of immune responses.This antibody, raised in rabbits, is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunohistochemistry. It specifically binds to the Y536 phosphorylated form of PTPN6, allowing for the detection and analysis of PTPN6 phosphorylation levels in different cell types and tissues.
Understanding the phosphorylation status of PTPN6 is essential for unraveling its role in immune regulation and its involvement in diseases such as cancer, autoimmune disorders, and inflammatory conditions. The PTPN6 (Y536) Polyclonal Antibody provides a powerful tool for researchers interested in studying the intricate mechanisms of immune signaling and developing targeted therapies for immune-related diseases.
Product Name:
Phospho-SHP1-Y536 Rabbit Polyclonal Antibody
SKU:
CABP0440
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A phospho specific peptide corresponding to residues surrounding Y536 of human PTPN6
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported.
Purification Method:
Affinity purification
Gene ID:
5777
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
