The Phospho-STING/TMEM173-S366 Monoclonal Antibody (CABP1369) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, derived from mouse hybridoma cells, is highly specific for detecting phosphorylation at serine 366 of the STING protein and is validated for use in immunofluorescence and immunoprecipitation assays.STING (Stimulator of Interferon Genes) is a crucial signaling molecule that activates the production of interferons and other cytokines in response to cytosolic DNA. Phosphorylation at serine 366 is known to be important for regulating STING activity and downstream signaling pathways.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
Phospho-STING/TMEM173-S366 Monoclonal Antibody
SKU:
CABP1369
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC57910
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:
LISG M
Tested Applications:
WBELISA
Recommended Dilution:
WB
1:1000 - 1:2000
ELISA
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
340061
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.09% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using Phospho-STING/TMEM173-S366 Rabbit mAb (CABP1369) at 1:1000 dilution. THP-1 cells were transfection with poly(dA:dT) (5μg/mL) for 3 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
