The Phospho-Synapsin-1 (S9) Polyclonal Antibody (CABP0244) is an essential tool for researchers studying synapsin-1, a key protein involved in synaptic vesicle trafficking and neurotransmitter release. This antibody, raised in rabbits, is highly specific to phosphorylated synapsin-1 at serine 9 and is validated for use in various applications such as Western blotting and immunofluorescence.Synapsin-1 is a critical regulator of neurotransmission in the brain, playing a vital role in the release of neurotransmitters and synaptic plasticity. Phosphorylation of synapsin-1 at serine 9 is known to modulate its function, impacting synaptic vesicle localization and release dynamics.
This makes the Phospho-Synapsin-1 (S9) Polyclonal Antibody a valuable tool for investigating synaptic transmission and plasticity in both normal neuronal function and pathological conditions such as neurodegenerative disorders and neurological diseases.With its high specificity and reliability, the Phospho-Synapsin-1 (S9) Polyclonal Antibody is an invaluable resource for researchers looking to delve into the intricate mechanisms of synaptic transmission and explore potential therapeutic targets for neurological conditions.
Product Name:
Phospho-SYN1-S9 Rabbit Polyclonal Antibody
SKU:
CABP0244
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S9 of human SYN1 (NP_008881.2).
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
6853
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse Brain tissue using Phospho-SYN1-S9 Rabbit pAb (CABP0244).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
