The PIGB Polyclonal Antibody (PAC011237) is a valuable tool for researchers studying the PIGB protein, a key component of the GPI-anchor biosynthesis pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the PIGB protein, researchers can accurately detect and analyze its expression in a variety of cell types.PIGB is integral to the formation of GPI-anchored proteins, which play essential roles in cellular processes such as signal transduction, protein trafficking, and immune response. Dysregulation of the GPI-anchor biosynthesis pathway has been linked to various diseases, including neurological disorders and cancer.
Thus, investigating the function and regulation of PIGB is crucial for gaining insights into these pathological conditions and potentially identifying new therapeutic targets.In summary, the PIGB Polyclonal Antibody is a reliable tool for exploring the role of PIGB in GPI-anchor biosynthesis and its implications in disease pathogenesis. Its specificity and sensitivity make it a valuable asset for researchers in the fields of biochemistry, cell biology, and molecular medicine.
phosphatidylinositol glycan anchor biosynthesis, class B;PIGB;MGC21236 ;
UniProt Protein Function:
PIGB: Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly. Belongs to the glycosyltransferase 22 family. PIGB subfamily.Protein type: Membrane protein, integral; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Transferase; Membrane protein, multi-pass; Endoplasmic reticulum; EC 2.4.1.-Chromosomal Location of Human Ortholog: 15q21.3Cellular Component: endoplasmic reticulum membrane; integral to membraneMolecular Function: mannosyltransferase activityBiological Process: cellular protein metabolic process; preassembly of GPI anchor in ER membrane; GPI anchor biosynthetic process; C-terminal protein lipidation; post-translational protein modification
UniProt Protein Details:
NCBI Summary:
This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases. [provided by RefSeq, Jul 2008]
