The PIK3C3 Polyclonal Antibody (CAB4021) is a valuable tool for researchers studying the PIK3C3 protein, which plays a critical role in autophagy, cell growth, and survival. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By targeting the PIK3C3 protein, this antibody enables the detection and analysis of PIK3C3 in various cell types, making it ideal for studies in cell biology, cancer research, and metabolism.PIK3C3, also known as phosphoinositide-3-kinase class III, is a key regulator of the autophagy pathway, which is essential for cellular homeostasis and the removal of damaged or dysfunctional components.
Dysregulation of PIK3C3 has been linked to a variety of diseases, including cancer, neurodegenerative disorders, and metabolic conditions. Investigating the function and expression of PIK3C3 using this antibody can provide valuable insights into the mechanisms underlying these diseases and potential therapeutic targets for intervention.
Product Name:
PIK3C3/VPS34 Rabbit Polyclonal Antibody
SKU:
CAB4021
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human PIK3C3/VPS34 (NP_002638.2).
Cytoplasmic vesicle, Late endosome, Midbody, autophagosome.
Calculated MW:
102kDa
Observed MW:
100kDa
Enables 1-phosphatidylinositol-3-kinase activity. Involved in early endosome to late endosome transport and regulation of cytokinesis. Acts upstream of or within autophagy and protein lipidation. Located in autolysosome; late endosome; and midbody.
Purification Method:
Affinity purification
Gene ID:
5289
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PIK3C3/VPS34 antibody (CAB4021).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
