The PITPNB Polyclonal Antibody (PACO06753) is a valuable tool for research involving PITPNB, a phosphatidylinositol transfer protein essential for lipid metabolism and cell signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in various applications, including Western blotting. By binding to the PITPNB protein, this antibody enables precise detection and analysis in different cell types, making it ideal for studies in molecular biology and lipid signaling pathways.
PITPNB is a key player in lipid transport and signaling, influencing processes such as vesicle trafficking, membrane biogenesis, and cell growth. Its critical role in lipid metabolism makes it a promising target for research into metabolic disorders, cancer, and neurodegenerative diseases. By elucidating the functions of PITPNB, researchers can gain insights into the mechanisms underlying these conditions and potentially identify therapeutic targets for intervention.
Antibody Name:
PITPNB Antibody (PACO06753)
Antibody SKU:
PACO06753
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:40000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from the Internal region of human PITP β .
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western Blot analysis of various cells using PITP beta Polyclonal Antibody.
Western Blot analysis of HepG2 cells using PITP beta Polyclonal Antibody.
Synonyms:
PITPNB; Phosphatidylinositol transfer protein β isoform; PI-TP-β; PtdIns transfer protein β; PtdInsTP β
UniProt Protein Function:
PITPNB: transfers phosphatidylinositol, phosphatidylcholine and sphingomyelin between membrane bilayers. Associates mainly with the trans-Golgi network. Ser-261 is constitutively phosphorylated.Protein type: Lipid-bindingChromosomal Location of Human Ortholog: 22q12.1Cellular Component: endoplasmic reticulum membrane; Golgi membraneBiological Process: phospholipid transport
UniProt Protein Details:
NCBI Summary:
This gene encodes a cytoplasmic protein that catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes. This transfer activity is required for COPI complex-mediated retrograde transport from the Golgi apparatus to the endoplasmic reticulum. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
