The Pituitary homeobox 2 (PITX2) Monoclonal Antibody (CAB22173) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in a monoclonal format, offers high specificity and sensitivity for detecting PITX2 in various experimental applications, including immunofluorescence and flow cytometry. Its reactivity with human samples has been extensively validated, ensuring reliable and reproducible results in research settings.PITX2 is known for its essential roles in embryonic development, particularly in the formation of the pituitary gland and other tissues. In addition, abnormalities in PITX2 expression have been implicated in various medical conditions, including pituitary disorders and certain cancers.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.
Product Name:
Pituitary homeobox 2 (PITX2) Monoclonal Antibody
SKU:
CAB22173
Size:
20μL, 100μL
Reactivity:
Human
Clone Number:
ARC56103
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Purification Method
Affinity purification
Gene ID
5308
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of lysates from HeLa cells, using Pituitary homeobox 2 (PITX2) Rabbit mAb (CAB22173) at1:2000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (AbGn00021). Exposure time: 90s.
