The PKIB Polyclonal Antibody (PACO51122) is a valuable tool for researchers studying PKIB, a protein kinase inhibitor that plays a crucial role in regulating cell signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to PKIB, the antibody enables accurate detection and analysis in a variety of cell types, making it an ideal choice for studies in signal transduction and cancer research.PKIB is known for its ability to modulate various protein kinase pathways, impacting cellular processes such as cell growth, differentiation, and survival.
Its involvement in these pathways makes PKIB a key target for research in cancer biology, as dysregulation of protein kinases is often implicated in tumor development and progression. By studying the function of PKIB, researchers can gain important insights into the molecular mechanisms underlying cancer and potentially identify new therapeutic targets for treatment.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO51122 at dilution of 1:100.
Immunofluorescent analysis of MCF-7 cells using PACO51122 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO51122 at dilution of 1:100.
Background:
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Synonyms:
cAMP-dependent protein kinase inhibitor β (PKI-beta), PKIB, PRKACN2
UniProt Protein Function:
PKIB: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. Belongs to the PKI family.
UniProt Protein Details:
Protein type:Protein kinase, regulatory subunit; Inhibitor
Chromosomal Location of Human Ortholog: 6q22.31
Cellular Component: cytoplasm; nucleus
Molecular Function:cAMP-dependent protein kinase inhibitor activity
NCBI Summary:
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
