The PLEKHG6 Polyclonal Antibody (PAC016724) is a valuable tool for researchers studying PLEKHG6, a protein involved in regulating cell signaling pathways. This antibody, produced in rabbits, exhibits high specificity for human samples and is suitable for use in Western blot applications. By binding to the PLEKHG6 protein, this antibody enables the detection and analysis of PLEKHG6 expression in a variety of cell types, making it an ideal choice for studies in cell biology and signal transduction research.PLEKHG6 is known to play a crucial role in modulating cell signaling cascades that impact cell growth, differentiation, and migration.
Research into the functions of PLEKHG6 has implications for understanding various cellular processes and disease mechanisms. By elucidating the role of PLEKHG6, researchers aim to uncover potential therapeutic targets for conditions such as cancer, neurodegenerative disorders, and cardiovascular diseases. This antibody is a valuable tool for investigating the functions of PLEKHG6 and its potential as a target for therapeutic intervention.
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO16724(PLEKHG6 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: PACO16724(PLEKHG6 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds.
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16724(PLEKHG6 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200).
Background:
PLEKHG6 functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.
Synonyms:
pleckstrin homology domain containing, family G (with RhoGef domain) member 6
UniProt Protein Function:
PLEKHG6: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GEFs; GEFs, Rac/RhoChromosomal Location of Human Ortholog: 12p13.31Molecular Function: protein binding
