Anti-PLXNB3 Antibody (CAB16064)

Antibody Name:	Anti-PLXNB3 Antibody
Antibody SKU:	CAB16064
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1250 of human PLXNB3 (NP_001156729.1).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Mouse
Positive Samples:	Mouse brain

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1050-1250 of human PLXNB3 (NP_001156729.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	RGGG RLIR VRGT GLDV VQRP LLSV WLEA DAEV QASR AQPQ DPQP RRSC GAPA ADPQ ACIQ LGGG LLQC STVC SVNS SSLL LCRS PAVP DRAH PQRV FFTL DNVQ VDFA SASG GQGF LYQP NPRL APLS REGP ARPY RLKP GHVL DVEG EGLN LGIS KEEV RVHI GRGE CLVK TLTR THLY CEPP AHAP QPAN GSGL PQFV V
Gene ID:	5365
Uniprot:	Q9ULL4
Cellular Location:	Cell membrane, Single-pass type I membrane protein
Calculated MW:	206kDa/209kDa
Observed MW:	170kDa

Synonyms:	PLXNB3, PLEXB3, PLEXR, PLXN6, plexin-B3
Background:	The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

UniProt Protein Function:	Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.
NCBI Summary:	The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
UniProt Code:	Q9ULL4
NCBI GenInfo Identifier:	253795481
NCBI Gene ID:	5365
NCBI Accession:	NP_001156729.1
UniProt Secondary Accession:	Q9ULL4,Q9HDA4, B7Z3E6, F5H773,
UniProt Related Accession:	Q9ULL4
Molecular Weight:	209,301 Da
NCBI Full Name:	plexin-B3 isoform 2
NCBI Synonym Full Names:	plexin B3
NCBI Official Symbol:	PLXNB3
NCBI Official Synonym Symbols:	PLEXR; PLXN6; PLEXB3
NCBI Protein Information:	plexin-B3
UniProt Protein Name:	Plexin-B3
Protein Family:	Plexin
UniProt Gene Name:	PLXNB3

Western blot analysis of extracts of mouse brain, using PLXNB3 antibody (CAB16064) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.

Antibodies

Anti-PLXNB3 Antibody (CAB14767)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)