The PPP1R16B Polyclonal Antibody (PAC039054) is a valuable tool for researchers studying PPP1R16B, a protein involved in cell cycle regulation and DNA damage response pathways. Raised in rabbits, this antibody is highly specific for human samples and is well-suited for use in Western blot applications. By targeting the PPP1R16B protein, this antibody allows for the detection and analysis of PPP1R16B expression in various cell types, making it an essential component in studies related to cell biology and cancer research.
PPP1R16B, also known as protein phosphatase 1 regulatory subunit 16B, plays a crucial role in maintaining genomic stability and controlling cell division. Dysregulation of PPP1R16B has been implicated in various cancers and genetic disorders, highlighting its importance in disease development and progression. By understanding the function of PPP1R16B, researchers can gain insights into potential therapeutic targets for treating conditions linked to aberrant cell growth and DNA damage.
Antibody Name:
PPP1R16B Antibody (PACO39054)
Antibody SKU:
PACO39054
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein phosphatase 1 regulatory inhibitor subunit 16B protein (101-400AA)
Immunohistochemistry of paraffin-embedded human lung tissue using PACO39054 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO39054 at dilution of 1:100.
Background:
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.
Synonyms:
Protein phosphatase 1 regulatory inhibitor subunit 16B (Ankyrin repeat domain-containing protein 4) (CAAX box protein TIMAP) (TGF-beta-inhibited membrane-associated protein) (hTIMAP), PPP1R16B, ANKRD4 KIAA0823
UniProt Protein Function:
PPP1R16B: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells.Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunitChromosomal Location of Human Ortholog: 20q11.23Cellular Component: cell projection; nucleus; perinuclear region of cytoplasm; plasma membraneMolecular Function: protein binding; protein phosphatase type 1 regulator activityBiological Process: negative regulation of protein amino acid dephosphorylation; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid dephosphorylation; regulation of filopodium formation; regulation of phosphoinositide 3-kinase cascade
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
