The Prion Protein Monoclonal Antibody (CAB8821) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, derived from rabbit monoclonal sources, exhibits high reactivity with human samples and has been extensively validated for use in Western blot applications.The Prion Protein Rabbit Monoclonal Antibody binds specifically to the prion protein, enabling highly sensitive detection and analysis in a variety of cell types. This makes it an essential tool for researchers studying prion diseases and related neurodegenerative disorders.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Mouse, Rat samples.
Product Name:
Prion Protein Monoclonal Antibody
SKU:
CAB8821
Size:
20μL, 100μL
Reactivity:
Mouse, Rat
Clone Number:
ARC1315
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
5621
RRID
AB_2863615
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Prion Protein Rabbit mAb (CAB8821) at 1:1000 dilution incubated at room temperature for 1.5 hours. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC): MCF7. Exposure time: 60 s.
