The Protocadherin-19 Polyclonal Antibody (CAB10067) is a valuable tool for researchers studying Protocadherin-19, a cell adhesion molecule that plays a key role in neuronal development and synapse formation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. It binds specifically to the Protocadherin-19 protein, allowing for accurate detection and analysis in various cell types, making it ideal for studies in neuroscience and developmental biology.
Protocadherin-19 is known for its involvement in neuronal connectivity and synaptic plasticity, making it a crucial target for research on neurodevelopmental disorders like epilepsy and autism. Understanding the functions of Protocadherin-19 can provide insight into the mechanisms underlying these conditions, potentially leading to the development of new treatments. The Protocadherin-19 Polyclonal Antibody is a reliable tool for researchers investigating the role of Protocadherin-19 in brain development and disease pathology.
Product Name:
PCDH19 Rabbit Polyclonal Antibody
SKU:
CAB10067
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 568-678 of human PCDH19 (NP_001171809.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
126kDa
Observed MW:
170kDa
The protein encoded by this gene is a member of the delta-2 protocadherin subclass of the cadherin superfamily. The encoded protein is thought to be a calcium-dependent cell-adhesion protein that is primarily expressed in the brain. Mutations in this gene on human chromosome X are associated with sporadic infantile epileptic encephalopathy and to a female-restricted form of epilepsy (EFMR; also known as PCDH19RE). Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
57526
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of 293T cells, using PCDH19 antibody (CAB10067) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
