The PROZ Antibody (CAB16082) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, exhibits high specificity and reactivity towards human samples, making it an excellent choice for Western blotting applications. By binding to the Proz protein, this antibody enables the detection and analysis of Proz in various cell types, providing valuable insights for studies in hemostasis, thrombosis, and related disorders.Proz, also known as protein Z, serves as a key player in the coagulation pathway, contributing to the regulation of blood clot formation and prevention of excessive bleeding.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
PROZ Antibody
SKU:
CAB16082
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
PZ, PROZ
Positive Sample:
HepG2, 293T, Mouse kidney, Rat liver, Rat kidney
Cellular Localization:
Secreted.
Calculated MW:
45kDa
Observed MW:
48kDa
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants.
Purification Method
Affinity purification
Gene ID
8858
RRID
AB_2763523
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PROZ Rabbit pAb (CAB16082) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
