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Purified Anti-Human CD45RO Antibody [UCHL1] (AGEL3509)

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SKU AGEL3509
Product Type Antibody
Antibody Type Monoclonal Antibody
Applications FCM
Reactivity Human
Host Species Mouse
Isotype Mouse IgG2a, k
Clone UCHL1
Conjugation Unconjugated
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Description

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Purified Anti-Human CD45RO Antibody [UCHL1]

The Purified Anti-Human CD45RO Antibody (UCHL1) from AssayGenie is a highly specific tool designed for research involving CD45RO, a cell surface glycoprotein primarily expressed on memory T cells and a subset of B cells. This antibody, sourced from UCHL1, a well-known biomarker for activated and memory T cells, provides reliable and accurate detection of CD45RO in human samples.With its exceptional specificity and sensitivity, the Purified Anti-Human CD45RO Antibody (UCHL1) is ideal for a range of applications including flow cytometry, immunohistochemistry, and immunofluorescence. It allows for precise identification and quantification of CD45RO-expressing cells in various tissues and biological samples, making it an invaluable tool for immunological research and clinical diagnostics.

Furthermore, the CD45RO molecule is integral to immune memory and T cell activation processes, playing a crucial role in adaptive immune responses. By utilizing the Purified Anti-Human CD45RO Antibody (UCHL1), researchers can gain deeper insights into the mechanisms underlying immune memory and T cell function, paving the way for advancements in vaccine development, autoimmune disease research, and immunotherapy strategies.Overall, the Purified Anti-Human CD45RO Antibody (UCHL1) from AssayGenie offers researchers a high-quality, validated tool to enhance their studies in immunology, infectious diseases, and beyond.

Product Title:Purified Anti-Human CD45RO Antibody [UCHL1]
SKU:AGEL3509
Size:25µg, 100µg
Clone No:UCHL1
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:Purified Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:Unconjugated
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Gene ID:5788
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines.

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