Purified Anti-Human CD45RO Antibody [UCHL1] (AGEL3509)
- SKU:
- AGEL3509
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Applications:
- FCM
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- Mouse IgG2a, k
- Clone:
- UCHL1
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Product Title: | Purified Anti-Human CD45RO Antibody [UCHL1] |
SKU: | AGEL3509 |
Size: | 25µg, 100µg |
Clone No: | UCHL1 |
Host Species: | Mouse |
Reactivity: | Human |
Application: | FCM |
Isotype: | Mouse IgG2a, κ |
Isotype Control: | Purified Mouse IgG2a, κ Isotype Control[C1.18.4] |
Form: | Liquid |
Conjugation: | Unconjugated |
Recommended Use: | Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application. |
Gene ID: | 5788 |
Storage Buffer: | Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer. |
Stability & Storage: | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
Background: | CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines. |