Description
RAB32 Antibody (PACO35498)
The Rab32 Polyclonal Antibody (PACO35498) is a valuable tool for researchers studying Rab32, a member of the Rab GTPase family involved in regulating intracellular membrane trafficking. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting Rab32 in human samples, making it suitable for use in Western blot applications. By targeting Rab32, researchers can investigate its role in controlling vesicle transport and organelle dynamics within cells, providing insights into cellular processes such as autophagy, endocytosis, and secretion.
Rab32 is a key player in maintaining the structural and functional integrity of organelles such as mitochondria and lysosomes, highlighting its importance in cellular homeostasis and metabolism. Dysregulation of Rab32 has been implicated in various diseases, including neurodegenerative disorders and cancer, underscoring the need for further research into its molecular mechanisms and potential therapeutic implications. The Rab32 Polyclonal Antibody is an essential tool for unraveling the complex functions of Rab32 and its impact on cellular physiology and pathology.
| Antibody Name: | RAB32 Antibody (PACO35498) |
| Antibody SKU: | PACO35498 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Ras-related protein Rab-32 protein (2-225AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: RAB32 antibody at 3µg/ml + Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 25 kDa. Observed band size: 25 kDa. |
| Background: | Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). |
| Synonyms: | Ras-related protein Rab-32, RAB32 |
| UniProt Protein Function: | RAB32: Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Belongs to the small GTPase superfamily. Rab family. |
| UniProt Protein Details: | Protein type:G protein, monomeric; G protein; G protein, monomeric, Rab Chromosomal Location of Human Ortholog: 6q24.3 Cellular Component: early endosome; melanosome; membrane; mitochondrion; phagocytic vesicle; trans-Golgi network Molecular Function:GTP-dependent protein binding; GTPase activity; protein binding Biological Process: antigen processing and presentation |
| NCBI Summary: | The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q13637 |
| NCBI GenInfo Identifier: | 2833245 |
| NCBI Gene ID: | 10981 |
| NCBI Accession: | Q13637.3 |
| UniProt Related Accession: | Q13637 |
| Molecular Weight: | 24,997 Da |
| NCBI Full Name: | Ras-related protein Rab-32 |
| NCBI Synonym Full Names: | RAB32, member RAS oncogene family |
| NCBI Official Symbol: | RAB32Â Â |
| NCBI Protein Information: | ras-related protein Rab-32 |
| UniProt Protein Name: | Ras-related protein Rab-32 |
| Protein Family: | Ras-related protein |
| UniProt Gene Name: | RAB32Â Â |
| UniProt Entry Name: | RAB32_HUMAN |
| Antibodies |
| RAB32 Antibody (PACO11648) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
