The Rab40B Polyclonal Antibody (PACO35438) is a valuable tool for researchers investigating the Rab40B protein, an important regulator of intracellular vesicle trafficking. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in a variety of applications, including Western blotting.Rab40B plays a crucial role in directing vesicle transport within cells, facilitating processes such as protein sorting, membrane fusion, and organelle movement. Dysregulation of Rab40B has been implicated in various diseases, including cancer, neurodegenerative disorders, and infectious diseases.
By targeting Rab40B with this antibody, researchers can gain valuable insights into the molecular mechanisms underlying these pathologies.This antibody enables the detection and analysis of Rab40B in different cell types, making it an essential tool for studies in cell biology, molecular biology, and drug discovery. By understanding the function and regulation of Rab40B, researchers can develop novel therapeutic strategies to target diseases associated with aberrant vesicle trafficking.
Antibody Name:
RAB40B Antibody (PACO35438)
Antibody SKU:
PACO35438
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Ras-related protein Rab-40B protein (1-278AA)
Immunohistochemistry of paraffin-embedded human brain tissue using PACO35438 at dilution of 1:100.
Background:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Synonyms:
Ras-related protein Rab-40B (SOCS box-containing protein RAR) (Protein Rar), RAB40B, SEC4L
UniProt Protein Function:
RAB40B: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Belongs to the small GTPase superfamily. Rab family.Protein type: G protein; G protein, monomeric; G protein, monomeric, RabChromosomal Location of Human Ortholog: 17q25.3Cellular Component: plasma membrane; endosome membraneMolecular Function: GTPase activity; GDP binding; GTP bindingBiological Process: regulation of exocytosis; intracellular protein transport; protein secretion; protein ubiquitination; Rab protein signal transduction; vesicle docking during exocytosis
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]
