The Rab6A Polyclonal Antibody (CAB5613) is a valuable tool for researchers studying Rab6A, a small GTPase protein involved in intracellular protein trafficking and membrane dynamics. This antibody, raised in rabbits, is highly specific and works effectively in a variety of applications, including immunofluorescence, immunoprecipitation, and immunohistochemistry.Rab6A plays a central role in regulating vesicle transport between the Golgi apparatus and the endoplasmic reticulum, as well as in retrograde transport from endosomes to the Golgi. Dysregulation of Rab6A has been implicated in various diseases, including neurodegenerative disorders and cancer.
By using the Rab6A Polyclonal Antibody, researchers can investigate the localization and function of Rab6A in different cell types and gain insight into its role in cellular processes.This antibody is essential for studies in cell biology, molecular biology, and neuroscience, providing researchers with a reliable tool to explore the complex functions of Rab6A and its implications in disease pathology. Its high specificity and sensitivity make it an indispensable reagent for researchers seeking to unravel the mysteries of intracellular transport and membrane trafficking mechanisms.
Product Name:
RAB6A Rabbit Polyclonal Antibody
SKU:
CAB5613
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RAB6A (NP_002860.2).
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
5870
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RAB6A antibody (CAB5613) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 30s.
