The 14-3-3 protein theta/YWHAQ product is a member of the 14-3-3 protein family, which binds to phosphoserine-containing proteins and acts as a signal transducer. 14-3-3 proteins are, in fact, components of the highly conserved protein family that can be found in both plants and animals. The orthologs from mice and rats are 99 percent identical. In persons with amyotrophic lateral sclerosis, 14-3-3 protein theta/YWHAQ is overexpressed. It has a polymorphic 6bp tandem repeat sequence in its 5' UTR. YWHAQ is linked to Creutzfeldt-Jakob disease and congenital fibrosis of the extraocular muscles. The 14-3-3 protein theta/YWHAQ pathways include two related processes: translocation of GLUT4 to the plasma membrane and constitutive signalling by AKT1 E17K in cancer.14-3-3 tau/14-3-3 theta/YWHAQ Recombinant Protein is a highly pure protein developed by Assay Genie for use in a range of applications.
14-3-3 tau/14-3-3 theta/YWHAQ Recombinant Protein (RPES0445)
Met 1-Asn 245
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A DNA sequence encoding the human YWHAQ (P27348) (Met 1-Asn 245) was fused with the GST tag at the N-terminus.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.