Description
| Product Name: | Recombinant Human ACVRL1 Protein (His Tag) |
| SKU: | RPES8303 |
| Size: | 20μg |
| Tag: | C-His |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | P37023 |
| Sequence: | Asp22-Gln118 |
| Calculated Molecular Weight: | 10.5 kDa |
| Observed Molecular Weight: | 25-30 kDa |
| Synonyms: | Activin A receptor, Activin A receptor type II like 1, Activin A receptor, type II like kinase 1, Activin receptor like kinase 1, Activin receptor-like kinase 1, ACVL1, ACVRL1, ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, Osler Rendu Weber syndrome 2, Serine/threonine protein kinase receptor R3, Serine/threonine-protein kinase receptor R3, SKR3, TGF B superfamily receptor type I, TGF-B superfamily receptor type I, TSR-I, TSR1 |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with an other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine-and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with an other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with an hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
