Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
Product Name:
Human BCL-W/BCL2L2 Recombinant Protein (RPES3400)
Product Code:
RPES3400
Size:
10µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
Bcl-2-Like Protein 2, Bcl2-L-2, Apoptosis Regulator Bcl-W, BCL2L2, BCLW, KIAA0271
Accession:
Q92843
Sequence:
Ala2-Thr172
Fusion tag:
C-6His
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human B Cell Lymphoma/Leukemia w is produced by our E.coli expression system and the target gene encoding Ala2-Thr172 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
19.9 kDa
AP Mol Mass:
18 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 25mM HEPES, 100mM KCl, 20% Glycerol, pH 7.5.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
