Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV); an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains; a transmembrane segment; and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (?; β; ?; and ?) with identical extracellular domains.
Product Name:
Human CD155/PVR/NECL5 Recombinant Protein (RPES0441)
Product Code:
RPES0441
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Poliovirus Receptor, Nectin-Like Protein 5, NECL-5, CD155, PVR, PVS
Accession:
P15151
Sequence:
Trp21-Asn343
Fusion tag:
C-mFc
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human NECL5 is produced by our Mammalian expression system and the target gene encoding Trp21-Asn343 is expressed with a mFc tag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
61.7 kDa
AP Mol Mass:
80-110 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
