The enzyme QDPR/Dihydropteridinereductase, is an enzyme that catalyses the reduction of quinonoid dihydrobiopterin by NADH. Dihydropteridinereductase is required for the hydroxylation of aromatic amino acids in pterin-dependent pathways. QDPR deficiency is caused by mutations in QDPR/Dihydropteridinereductase, including aberrant splicing, amino acid substitutions, insertions and truncations. QDPR has been linked to a variety of diseases, including: hyperphenylalaninemia, Bh4-deficiency, C, and tetrahydrobiopterin deficiency. Two QDPR/Dihydropteridinereductase-related processes are phenylalanine degradation/tyrosine synthesis and viral mRNA translation.QDPR Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Recombinant Human Dihydropteridine Reductase is produced by our Mammalian expression system and the target gene encoding Ala2-Phe244 is expressed with a 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
26.8 kDa
AP Mol Mass:
29 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM TrisHCl,pH8.0.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
