Description
| Product Name: | Recombinant Human Galectin-9/LGALS9 (N-GST) |
| Product Code: | RPES6250 |
| Size: | 10µg |
| Species: | Human |
| Expression Host: | E.coli |
| Synonyms: | Galectin-9, Gal-9, Ecalectin, Tumor antigen HOM-HD-21, LGALS9, Gal-9delta5 |
| Mol Mass: | 62.2 kDa |
| AP Mol Mass: | 60 kDa |
| Tag: | N-GST |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin Level: | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Bio Activity: | Testing in progress |
| Sequence: | Met1-Thr322 |
| Accession: | O00182-2 |
| Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation: | Supplied as a 0.2 μm filtered solution of 1M PBS, 100 mM GSH, 1% Tritonx-100, 15% Glycerol, pH 8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer inform |
| Reconstitution: | Not Applicable |
| Background: | Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin α4β1 |
