Description
Recombinant Human IL-17A/CTLA-8 Protein
The Recombinant Human IL-17A/CTLA-8 Protein is a biologically active recombinant protein that plays a significant role in various cellular processes and signaling pathways in human biology. This protein is widely employed in immunological research, cell biology studies, protein-protein interaction analyses, and therapeutic development, providing researchers with a reliable tool for investigating IL-17A/CTLA-8 function and its implications in health and disease.
This product (SKU: RPCB0271) is produced using HEK293 cells and features a C-His tag for convenient detection and purification. The protein exhibits a calculated molecular weight of 16.37 kDa with an observed molecular weight of 18-25 kDa under denaturing conditions, achieving ≥ 95 % as determined by SDS-PAGE.. Functional bioactivity has been validated through rigorous quality control assays, confirming its suitability for demanding research applications.
Key Features
| High Purity by Affinity Chromatography | |
| Mammalian & Bacterial Expression Systems | |
| High lot-to-lot consistency via strict QC |
| Product Name: | Recombinant Human IL-17A/CTLA-8 Protein |
| SKU: | RPCB0271 |
| Size: | 10 μg , 20 μg , 50 μg , 100 μg |
| Reactivity: | Human |
| Synonyms: | IL17A, CTLA-8, CTLA8, IL-17, IL-17A, IL17, interleukin-17A, CTLA-8, CTLA8, IL-17, IL-17A, IL17 |
| Tag: | C-His |
| Expression Host: | HEK293 cells |
| Calculated MW: | 16.37 kDa |
| Observed MW: | 18-25 kDa |
| Gene ID: | 3605 |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Human IL-17A/CTLA-8 Protein (RPCB0271), tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 0.1 EU/μg of the protein by LAL method. |
| Purity: | ≥ 95 % as determined by SDS-PAGE. |
| Formulation: | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.Contact us for customized product form or formulation. |
| Bio-Activity: |
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| Reconstitution: | Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
IL17, also known as IL17a and CTLA8, is a is a 15-20 kDa glycosylated cytokine which belongs to the IL-17 family. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL17A promotes protective mucosal and epidermal inflammation in response to microbial infection.It induces chemokine production, neutrophil influx, and the production of antibacterial peptides.IL17A additionally enhances the production of inflammatory mediators by rheumatoid synovial fibroblasts and contributes to TNF alpha induced shock. In contrast, it can protect against the progression of colitis by limiting chronic inflammation. IL17A encourages the formation of autoreactive germinal centers and exacerbates the onset and progression of experimental models of autoimmunity.
 | Recombinant Human IL-17A/CTLA-8 Protein was determined by SDS-PAGE under reducing conditions with Coomassie Blue. |
 | Immobilized Recombinant human IL17RA, His Tag at 2 μg/mL (100 μL/well) can bind Recombinant human IL-17A,The EC50 of human IL-17A is 32.5-130 ng/mL. |
