Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Product Name:
Human Interleukin3/IL3 Recombinant Protein (RPES3746)
Product Code:
RPES3746
Size:
10µg
Species:
Human
Expressed Host:
HEK293 Cells
Synonyms:
ALRH,IL-13,P600,IL13
Accession:
AAK53823.1
Sequence:
Gly 21-Asn 132
Fusion tag:
Fc Tag
Activity:
Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL13RA2 at 8 µg/ml (100 ?l/well) can bind IL13 with a linear range of 0.25-8.0 ng/ml.
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
A DNA sequence encoding the mature form of human IL13 (AAK53823.1) (Gly 21-Asn 132) was fused with the Fc region of human IgG1 at the N-terminus.
Purity:
> 98 % as determined by reducing SDS-PAGE.
Mol Mass:
39 kDa
AP Mol Mass:
50-55 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
