BMP-2 protein plays an important role in the development of bone and cartilage, like other bone morphogenetic proteins. The hedgehog pathway, TGF beta signalling pathway, and cytokine-cytokine receptor interaction are all affected by BMP-2. The BMP-2 and BMP-7 genes encode osteogenic BMPs that have been shown to effectively induce osteoblast differentiation in a variety of cell types. BMP-2, BMP-4, and BMP-7 are known to be critical in the formation and repair of bones. BMP-2 protein is present in malignant tissues and may be important in the development of glioma. Rhesus/Canine BMP-2 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Rhesus/Canine BMP-2 Recombinant Protein (RPES1020)
Product Code:
RPES1020
Size:
5µg
Species:
Human
Expressed Host:
E.coli
Synonyms:
BDA2,BDA2A,BMP-2,BMP2A,BMP2
Accession:
NP_001191.1
Sequence:
Gln283-Arg396
Fusion tag:
Activity:
Measured by its ability to induce alkaline phosphatase production by MC3T3-E1 mouse osteoblastic cells. The ED50 for this effect is typically 0.5-2 µg/ml.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the mature form of human BMP2 (NP_001191.1) (Gln283-Arg396) was expressed. The mature form sequences of human, mouse, rat, rhesus and canine BMP2 are identical.
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
