Pro-neuregulin-1; Neuregulin-1 beta 1 (NRG1) is a single-pass type I membrane protein in the neuregulin family. NRG1 contains 1 EGF-like and 1 Ig-like C2-type (immunoglobulin-like) domain. NRG1 is aDirect ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Proteins simultaneously engage ERBB1 and ERBB2 coreceptors, which causes ligand-activated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms of NRG1 performs diverse functions such as inducing growth and differentiation of epithelial; glial; neuronal; and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Pro-Neuregulin/NRG1-beta 1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Product Name:
Pro-Neuregulin/NRG1-beta 1 Recombinant Protein (RPES2769)
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Neuregulin-1 beta is produced by our E.coli expression system and the target gene encoding Ser2-Lys246 is expressed.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
26.9 kDa
AP Mol Mass:
34 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 4mM HCl.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
