null

Human TNFRSF1B/CD120b Recombinant Protein (RPES1622)

SKU:
RPES1622
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death
$265
Frequently bought together:

Description

system_update_altDatasheet

Human TNFRSF1B/CD120b Recombinant Protein

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD; which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs; respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage; such as T and natural killer cells; as well as on endothelial cells; microglia; astrocytes;neurons; oligodendrocytes; cardiac myocytes; thymocytes; and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNF? and Lymphotoxin?/TNFβ?soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.