IL23R, also known as IL23 receptor, belongs to the type I cytokine receptor family, Type 2 subfamily. It contains 2 fibronectin type-III domains and is expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells. IL23R associates with IL12RB1 to form the interleukin-23 receptor. It binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. Genetic variations in IL23R also can cause susceptibility to psoriasis type 7.
Product Name:
Rat IL23R/IL23 Receptor Recombinant Protein (RPES4403)
Product Code:
RPES4403
Size:
50 µg
Species:
Rat
Expressed Host:
HEK293 Cells
Synonyms:
IL23R
Accession:
XP_003753958.1
Sequence:
Met1-Asp367
Fusion tag:
C-Fc
Activity:
Measured by its ability to bind recombinant mouse IL12Bh (m)+mIL23Ah in a functional ELISA.
Endotoxin:
Please contact us for more information.
Protein Construction:
A DNA sequence encoding the rat IL23R (Met1-Asp367) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Purity:
(75.1+16.6) as determined by SDS-PAGE
Mol Mass:
69.4 kDa
Formulation:
Lyophilized from sterile PBS, pH 7.4
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
