Description
RGS11 Antibody (PACO16976)
The RGS11 Polyclonal Antibody (PAC016976) is a valuable tool for researchers studying RGS11, a member of the regulator of G-protein signaling (RGS) family known for its role in signal transduction and cellular communication. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications. By binding to the RGS11 protein, this antibody enables precise detection and analysis in a variety of cell types, making it particularly useful for investigations in molecular biology and neuroscience.
RGS11 acts as a key regulator of G-protein signaling pathways, influencing processes such as neurotransmission, cardiac function, and hormone release. Its involvement in these crucial cellular functions makes it a promising target for research on diseases like neurological disorders, cardiovascular conditions, and endocrine abnormalities. By gaining insight into the mechanisms of RGS11 activity, researchers can pave the way for innovative therapies aimed at addressing these challenging health issues.
| Antibody Name: | RGS11 Antibody (PACO16976) |
| Antibody SKU: | PACO16976 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human RGS11 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO16976(RGS11 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the α subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein α subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. |
| Synonyms: | regulator of G-protein signaling 11 |
| UniProt Protein Function: | RGS11: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: cytoplasm; plasma membrane; protein complex Molecular Function:G-protein beta-subunit binding; GTPase activator activity Biological Process: regulation of G-protein coupled receptor protein signaling pathway |
| NCBI Summary: | The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2013] |
| UniProt Code: | O94810 |
| NCBI GenInfo Identifier: | 6174947 |
| NCBI Gene ID: | 8786 |
| NCBI Accession: | O94810.2 |
| UniProt Secondary Accession: | O94810,O75883, Q4TT71, Q4TT72, |
| UniProt Related Accession: | O94810 |
| Molecular Weight: | 50,727 Da |
| NCBI Full Name: | Regulator of G-protein signaling 11 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 11 |
| NCBI Official Symbol: | RGS11Â Â |
| NCBI Official Synonym Symbols: | RS11Â Â |
| NCBI Protein Information: | regulator of G-protein signaling 11 |
| UniProt Protein Name: | Regulator of G-protein signaling 11 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS11Â Â |
| UniProt Entry Name: | RGS11_HUMAN |
